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JNJ-46281222

カタログ番号GC39393

JNJ-46281222 は、ナノモルの親和性 (Kd = 1.7 nM) と高い調節効力 (pEC50 = 7.71) を備えた、代謝型グルタミン酸 (mGlu) 2 選択的で非常に強力な PAM (ポジティブ アロステリック モジュレーター) です 。

Products are for research use only. Not for human use. We do not sell to patients.

JNJ-46281222 化学構造

Cas No.: 1254980-38-5

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$459.00
在庫あり
5mg
$417.00
在庫あり
10mg
$695.00
在庫あり
50mg
$2,086.00
在庫あり
100mg
$3,569.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

[1]. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.

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