BO-264 |
カタログ番号GC39483 |
BO-264 は、188 nM の IC50 と 1.5 nM の Kd を持つ、非常に強力で経口的に活性なトランスフォーミング酸性コイルドコイル 3 (TACC3) 阻害剤です。 BO-264 は、FGFR3-TACC3 融合タンパク質の機能を特異的にブロックします。 BO-264 は、スピンドル アセンブリ チェックポイント (SAC) 依存性の有糸分裂停止、DNA 損傷、およびアポトーシスを誘導します。 BO-264 は広範囲の抗腫瘍活性を持っています。
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Cas No.: 2408648-20-2
Sample solution is provided at 25 µL, 10mM.
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1].
[1]. Akbulut O, et al. A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate. Mol Cancer Ther. 2020 Mar 26. pii: molcanther.0957.2019.
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