ELN 318463 |
| カタログ番号GC39629 |
ELN 318463 は、アミロイド前駆体タンパク質 (APP) 選択的 γ-セクレターゼ阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 851600-86-7
Sample solution is provided at 25 µL, 10mM.
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ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1[1][2].
[1]. Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283(5):2927-38. [2]. Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2(6):36.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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