Difelikefalin (Synonyms: CR-845; FE-202845) |
| カタログ番号GC60137 |
ディフェリケファリン (CR-845; FE-202845) は、カッパオピオイド受容体 (KOR) の末梢限定的かつ選択的なアゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1024828-77-0
Sample solution is provided at 25 µL, 10mM.
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Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].
Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].
[1]. Steven Fishbane, et al. Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients. Kidney Int Rep. 2020 Jan 28;5(5):600-610. [2]. Steven Fishbane, et al. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients With Pruritus. N Engl J Med. 2020 Jan 16;382(3):222-232.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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