VHL Ligand 8 |
カタログ番号GC60379 |
VHL Ligand 8 は VHL リガンドです。 VHL Ligand 8 は、非常に強力な VHL E3 リガーゼベースのアンドロゲン受容体 (AR) PROTAC デグレーダーである ARD-266 の合成に使用できます。 ARD-266 は、AR 陽性の LNCaP、VCaP、および 22Rv1 前立腺癌細胞株において、0.2 ~ 1 nM の DC50 値で AR タンパク質の分解を効果的に誘導します。
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Sample solution is provided at 25 µL, 10mM.
VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 , a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].
[1]. Han X, Zhao L, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.
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