(Rac)-Benpyrine |
| カタログ番号GC18773 |
ベンピリンのラセミ体である (Rac)-ベンピリン は、経口で有効な強力な TNF-α 阻害剤です。
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Cas No.: 1333714-43-4
Sample solution is provided at 25 µL, 10mM.
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(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].
(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].
Reference:
[1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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