Desmorpholinyl Quizartinib-PEG2-COOH |
| カタログ番号GC60760 |
Desmorpholinyl Quizartinib-PEG2-COOH には、FLT-3 のリガンドと、PEG ベースの PROTAC リンカーが組み込まれています。 Desmorpholinyl Quizartinib-PEG2-COOH は、PROTAC FLT-3 デグレーダー 1 の合成に使用できます。PROTAC FLT-3 デグレーダー 1 は、IC50 0.6 nM の PROTAC FLT-3 内部タンデム複製 (ITD) デグレーダーです。
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Cas No.: 2292116-14-2
Sample solution is provided at 25 µL, 10mM.
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Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 . PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM[1].
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
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