DM-01 |
| カタログ番号GC60785 |
DM-01 は、びまん性大細胞型 B 細胞性リンパ腫 (DLBCL)、濾胞性リンパ腫 (FL)、および SNF5/INI-1/SMARCB1 遺伝的に定義された固形腫瘍の研究のための強力かつ選択的な EZH2 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2355280-00-9
Sample solution is provided at 25 µL, 10mM.
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DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1].
Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μμ[1]. DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells[1].DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2[1]. Cell Viability Assay[1] Cell Line: A549 sh-EV and A549 sh-EZH2 cells
[1]. Qifan Zhou, et al. Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents. New Journal of Chemistry. 10 Jan 2020.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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