Manool |
| カタログ番号GC61028 |
マヌールは、サルビア オフィシナリス由来のジテルペンです。マノールは、がん細胞に選択的な細胞毒性を誘発します。マヌールは、細胞周期の G(2)/M 期で癌細胞を停止させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 596-85-0
Sample solution is provided at 25 µL, 10mM.
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Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].
Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1].Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].
[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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