PRI-724 |
| カタログ番号GC61205 |
PRI-724（C-82プロドラッグ、ICG-001アナログ）は、βカテニンとCBPの相互作用を妨げる強力で特異的な阻害剤です。
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Cas No.: 1422253-38-0
Sample solution is provided at 25 µL, 10mM.
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PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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