(1S,3R)-3-Hydroxycyclopentane carboxylic acid benzyl ester |
| カタログ番号GC46325 |
多様な生物学的活性を持つ神経ペプチド
Products are for research use only. Not for human use. We do not sell to patients.
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Sample solution is provided at 25 µL, 10mM.
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CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).1 It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.
1.Wong, L., Tan, S.L., Lam, Y., et al.Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinasesJournal of Medicinal Chemistry523618-3626(2009)
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