Ganciclovir-d5 (Synonyms: 2’-Nor-2’-deoxyguanosine-d5)

Ganciclovir-d₅ is intended for use as an internal standard for the quantification of ganciclovir by GC- or LC-MS. Ganciclovir is a synthetic analog of 2'-deoxy-guanosine that inhibits the replication of human cytomegalovirus (CMV) with an IC₅₀ value of 0.01 μM.^1,2 It is effective against strains of CMV from human, monkey, mouse, and guinea pig.^1,2 Formulations containing ganciclovir have been used to treat or prevent CMV infections.^3,4

1.Rasmussen, L., Chen, P.T., Mullenax, J.G., et al.Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferonsAntimicrob. Agents Chemother.26(4)441-445(1984) 2.Freitas, V.R., Smee, D.F., Chernow, M., et al.Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesAntimicrob. Agents Chemother.28(2)240-245(1985) 3.Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev.Infect.Dis.12(Suppl. 7)S849-S860(1990) 4.Bean, B.Antiviral therapy: Current concepts and practicesClin.Microbiol.Rev.5(2)146-182(1992)