Myceliothermophin E |
| カタログ番号GC47711 |
抗がん作用と抗微生物活性を持つ真菌代謝産物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 955083-90-6
Sample solution is provided at 25 µL, 10mM.
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Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found in T. thermophilus and has anticancer and antimicrobial activities.1,2 It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC50s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).1 Myceliothermophin E is active against methicillin-resistant, but not -sensitive, S. aureus (MICs = 15.8 and >100 μM, respectively).2
1.Gao, Y.-L., Zhang, M.-L., Wang, X., et al.Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from Thermothelomyces thermophilus ATCC 42464Nat. Prod. Res.Epub ahead of print(2019) 2.Wang, X., Zhao, L., Liu, C., et al.New tetramic acids comprising of decalin and pyridones from Chaetomium olivaceum SD-80A with antimicrobial activityFront. Microbiol.102958(2020)
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