Temozolomide-d3 (Synonyms: Methazolastone-d3, TMZ-d3) |
カタログ番号GC48141 |
テモゾロミド-d3 (NSC 362856-d3) は、テモゾロミドとラベル付けされた重水素です。テモゾロミド (NSC 362856) は、血液脳関門を通過する経口活性 DNA アルキル化剤です。テモゾロミドは、プロオートファジーおよびプロアポトーシス剤でもあります。テモゾロミドは、低レベルの O6-アルキルグアニン DNA アルキルトランスフェラーゼ (OGAT) と機能的なミスマッチ修復システムを特徴とする腫瘍細胞に対して有効です。テモゾロミドには、抗腫瘍効果と抗血管新生効果があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 208107-14-6
Sample solution is provided at 25 µL, 10mM.
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.1 TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.1 Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.1,2,3
1.Marchesi, F., Turriziani, M., Tortorelli, G., et al.Triazene compounds: Mechanism of action and related DNA repair systemsPharmacol. Res.56(4)275-287(2007) 2.Khan, O.A., Ranson, M., Michael, M., et al.A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancerBr. J. Cancer98(10)1614-1618(2008) 3.Daniel, R.A., Rozanska, A.L., Mulligan, E.A., et al.Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699Br. J. Cancer103(10)1588-1596(2010)
Average Rating: 5
(Based on Reviews and 6 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *