UR-144 N-pentanoic acid metabolite-d5 (Synonyms: XLR11 Npentanoic acid metabolited5)

UR-144 N-pentanoic acid metabolite-d₅ contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of UR-144 N-pentanoic acid metabolite by GC- or LC-mass spectrometry (MS). UR-144 is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB₂ receptor (K_i = 1.8 nM) over the central CB₁ receptor (K_i = 150 nM).¹ UR-144 N-pentanoic acid metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.^2,3 This metabolite should be detectable in either serum or urine.^2,3 The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

1.Frost, J.M., Dart, M.J., Tietje, K.R., et al.Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activityJ. Med. Chem.53(1)295-315(2010) 2.Wintermeyer, A., MÖller, I., Thevis, M., et al.In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Anal. Bioanal. Chem.398(5)2141-2153(2010) 3.Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al.Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urineAnal. Chem.83(16)6381-6388(2011)