Pipemidic Acid (hydrate) |
| カタログ番号GC48684 |
抗生物質
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72571-82-5
Sample solution is provided at 25 µL, 10mM.
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Pipemidic acid is an antibiotic and derivative of piromidic acid .1 It is active against clinical isolates of E. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, and V. parahaemolyticus (MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates of E. coli, P. mirabilis, Klebsiella, and Shigella (MICs = 1.56-6.25 µg/ml). Pipemidic acid is protective against systemic S. aureus, E. coli, K. pneumoniae, and P. aeruginosa infections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively).2 It is also protective against P. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well as E. coli, K. pneumoniae, and P. aeruginosa urinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice.
1.Shimizu, Y., Takase, Y., Nakamura, S., et al.Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: In vitro propertiesAntimicrob. Agents Chemother.8(2)132-138(1975) 2.Shimizu, M., Takdase, Y., Nakamura, S., et al.Pipemidic acid: Its activities against various experimental infectionsAntimicrob. Agents Chemother.9(4)569-574(1976)
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