ML-SI1 (Synonyms: DMSO : 100 mg/mL (222.53 mM; Need ultrasonic)) |
カタログ番号GC19764 |
ML-SI1は、ジアステレオマーのラセミ混合物であり、TRPML1に対するIC50値が15μMのTRPML阻害剤です。
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Sample solution is provided at 25 µL, 10mM.
ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1.
ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments confirmed that the synthesized racemic ML-SI1 (10 μM) has an inhibitory effect on hTRPML1[1].
Reference:
[1]. Charlotte Leser, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
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