MIV-247 |
| カタログ番号GC31106 |
MIV-247 は、ヒト、マウス、カニクイザルのカテプシン S に対する Kis がそれぞれ 2.1、4.2、7.5 nM の選択的カテプシン S 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1352817-76-5
Sample solution is provided at 25 µL, 10mM.
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MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuates mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions[1].
[1]. Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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