CAY10621 (Synonyms: SKI 5C, SPHK1 Inhibitor 5C) |
| カタログ番号GC43183 |
CAY10621 (SKI 5C; 化合物 5c) は、IC50 が 3.3 μM の特異的なスフィンゴシンキナーゼ 1 (SPHK1) 阻害剤です。 CAY10621 は細胞に対して毒性が低いです。 CAY10621 には、耐性のあるがん腫瘍研究の可能性があります。
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Cas No.: 120005-55-2
Sample solution is provided at 25 µL, 10mM.
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CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).[1] It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.
Reference:
1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. Journal of Medicinal Chemistry 52, 3618-3626 (2009).
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