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CRT0066101 (hydrochloride)

カタログ番号GC43326

プロテインキナーゼD(PKD)は、一般的にPKCシグナルの下流でジアシルグリセロールによって活性化されるセリン/スレオニンプロテインキナーゼです。

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CRT0066101 (hydrochloride) 化学構造

Cas No.: 1290629-45-6

サイズ 価格 在庫数 個数
1mg
$46.00
在庫あり
5mg
$139.00
在庫あり
10mg
$255.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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