GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat) (trifluoroacetate salt) (Synonyms: Glucagon-like Peptide-1 (7-37) (human, bovine, guinea pig, mouse, rat)) |
カタログ番号GC43763 |
グルカゴン様ペプチド-1(GLP-1)(7-37)は内因性のインクレチンホルモンであり、膵臓と腸で前駆体グルカゴンの切断によって生成されるGLP-1(1-37)の切り詰められた形式です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine. It binds to βTC-1 and RIN 1027-B2 cells (Kds = 3.3 and 3.5 nM, respectively) and enhances insulin secretion in βTC-1 cells in a concentration- and glucose-dependent manner. Ex vivo, GLP-1 (7-37) stimulates insulin release from perfused rat pancreas. GLP-1 (7-37) increases plasma insulin concentrations by greater than 50% as compared to vehicle control in response to hyperglycemia in rats when administered at a dose of 15 pmol/min/kg for five days.
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