NBD-FTY720 phenoxy (hydrochloride) |
| カタログ番号GC44323 |
FTY720は免疫調節剤であり、スフィンゴシン-1-リン酸（S1P）受容体をダウンレギュレーションし、スフィンゴシントランスポーターAbcb1および白血球トリエヌC4トランスポーターAbcc1の活性を高め、細胞質リン脂質A2活性を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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FTY720 is an immune modulator that down-regulates sphingosine-1-phosphate (S1P) receptors, enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1, and inhibits cytosolic phospholipase A2 activity. It is known that some of the effects of FTY720 require its phosphorylation by sphingosine kinases in vivo, with FTY720-phosphate binding to and down-regulating S1P receptors. NBD-FTY720 is a fluorescently-labeled analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, suggesting that it would likewise be phosphorylated in vivo.
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