Substance P (trifluoroacetate salt) |
| カタログ番号GC44959 |
サブスタンスPは、神経キニンペプチドであり、選択的に神経キニン1（NK1）受容体に結合します（NK1およびNK3のKisはそれぞれ0.14および300 nMです）。また、多様な生物学的活性を持っています。
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Sample solution is provided at 25 µL, 10mM.
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Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities. It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in immune cells. Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK1 receptors. The NK1 receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia. Substance P is also involved in depression, anxiety, seizures, and emesis among other functions.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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