CAY10625 |
カタログ番号GC41317 |
サバイビンは、Smac/DIABLO、カスパーゼ-3、およびカスパーゼ-7を含むいくつかのタンパク質と相互作用してアポトーシス機能を阻害することにより細胞生存に関与する細胞内タンパク質です。
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Cas No.: 137346-42-0
Sample solution is provided at 25 µL, 10mM.
Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7. Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 µM. It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 µM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.
Average Rating: 5
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