CAY10678 (Synonyms: mPGES-1 Inhibitor III) |
| カタログ番号GC18904 |
マイクロソーマルプロスタグランジンE合成酵素1（mPGES-1）は、COX生成物であるPGH2を生物学的に活性なPGE2に変換します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1268709-57-4
Sample solution is provided at 25 µL, 10mM.
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Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2. Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α. CAY10678 is a benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC50 = 0.09 and 0.9 uM, respectively). It has minimal effects on COX-1, COX-2, PGIS, and hematopoietic PGDS at 50 μM but reduces lipocalin-type PGDS activity by 60% at this concentration. CAY10678 dose-dependently blocks PGE2 synthesis in isolated cells and whole blood treated with LPS or IL-1β. It also dose-dependently reduces PGE2 synthesis and cell recruitment during inflammation in mice.
Review for CAY10678
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
Review for CAY10678
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