CAY10771 |
| カタログ番号GC48426 |
FXRとPPARδの二重アゴニスト
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2522599-79-5
Sample solution is provided at 25 µL, 10mM.
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CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1 It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 µM.
1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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