CC-99677 |
| カタログ番号GC63441 |
CC-99677 は、生化学的アッセイ (IC50 = 156.3 nM) および細胞ベースのアッセイ (EC50 = 89 nM) の両方において、マイトジェン活性化タンパク質 (MAP) キナーゼ活性化プロテインキナーゼ-2 (MK2) 経路の強力で共有結合的かつ不可逆的な阻害剤です。 ）。
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Cas No.: 1887069-10-4
Sample solution is provided at 25 µL, 10mM.
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CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). CC-99677 is extracted from patent WO2020236636, compound 1[1].
CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM)[1].
[1]. WO2020236636
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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