Cjoc42 |
| カタログ番号GC64649 |
Cjoc42はガンキリンに結合する化合物です。 Cjoc42 は用量依存的にガンキリン活性を阻害します。 Cjoc42 は、通常大量のガンキリンに関連する p53 タンパク質レベルの低下を防ぎます。 Cjoc42 は、p53 依存性の転写と DNA 損傷に対する感受性を回復します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2171519-89-2
Sample solution is provided at 25 µL, 10mM.
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Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage[1].
cjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells[1].cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability[1].
[1]. Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732.
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