CM398 |
| カタログ番号GC63801 |
CM398 は、選択性の高い経口活性シグマ 2 受容体リガンド (Ki = 0.43 nM) であり、高いシグマ 1/シグマ 2 選択率 (1000 倍) を備えています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1121931-70-1
Sample solution is provided at 25 µL, 10mM.
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CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice[1].
[1]. Intagliata S, et al. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. AAPS J. 2020;22(5):94. Published 2020 Jul 20.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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