CMPF-d5

CMPF-d₅ contains five deuterium atoms at the 2, 2', 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of CMPF by GC- or LC-mass spectrometry. Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.¹ CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).^2,3 CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.³ Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.³

1.Ishii, K., Okajima, H., Okada, Y., et al.Studies on furan fatty acids of salmon roe phospholipidsJournal of Biochemistry103(5)836-839(1988) 2.Lim, C.F., Bernard, B.F., De Jong, M., et al.A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremiaJournal of Clinical Endocrinology and Metabolism76(2)318-324(1993) 3.Lim, C.F., Stockigt, J.R., Curtis, A.J., et al.A naturally occuring furan fatty acid enhances drug inhibition of thyroxine binding in serumMetabolism42(11)1468-1474(1993)