Coenzyme B12 |
| カタログ番号GC43296 |
コエンザイム B12 (コエンザイム B12; コバマミド; AdoCbl) は、ビタミン B12 の活性型であり、メチルマロニル CoA ムターゼ [1] の補因子です。インビトロ: コエンザイム B12 は、異常な再配列または除去反応を触媒する酵素群の補因子として機能します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13870-90-1
Sample solution is provided at 25 µL, 10mM.
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Coenzyme B12 (adenosylcobalamin; AdoCbl) is a biologically active form of vitamin B12 . It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea. It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase. These enzymes catalyze reactions that generate free radicals through release of the adenosyl group, allowing usually unreactive molecules to become reactive. Only one of these enzymes, methylmalonyl CoA mutase, is found in mammals, therefore, the other enzymes must be taken in through the diet. Genetic mutations in enzymes that synthesize AdoCbl lead to AdoCbl deficiency and methylmalonic aciduria. Formulations containing AdoCbl are used to treat patients with this disorder.
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