Cyclic di-IMP (sodium salt) (Synonyms: c-di-IMP, Cyclic di-inosine monophosphate) |
| カタログ番号GC43340 |
環状二IMP（ナトリウム塩）（c-di-IMP）は、細菌の第2メッセンジャーである環状二GMPおよび環状二AMPに構造的に関連する合成第2メッセンジャーです。
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Sample solution is provided at 25 µL, 10mM.
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Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) plus c-di-IMP through the intranasal route show a humoral immune response, evidenced by an increase in IgG titers up to 2-fold compared to mice immunized with β-gal alone. Mice immunized with β-gal plus c-di-IMP also exhibit a Th1/Th2 response, indicating that the adjuvant activity of c-di-IMP leads to a cellular immune response as well.
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