D-Sedoheptulose 7-phosphate |
| カタログ番号GC61494 |
D-セドヘプツロース 7-リン酸は、セプタシジン (グループ III) およびハイグロマイシン B (グループ IV) のヘプトースの一般的な前駆体です。
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Cas No.: 2646-35-7
Sample solution is provided at 25 µL, 10mM.
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D-Sedoheptulose 7-phosphate is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose 7-phosphate can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds [1].
Sedoheptulose 7-phosphate can be converted to ADP-l-glycero-β-d-manno-heptose by SepB, SepL, and SepC, it involves in ADP-sugar in microbial natural product biosynthesis[1].SepB is an S-7-P isomerase, SepL involves in the biosynthesis of heptoses of the core region of E. coli LPS, and they catalyze a four-reaction relay converting S-7-P into ADP-d-glycero-β-d-manno-heptose [1].Septacidin and its analogs are potential anticancer and pain-relief agents[1].Hygromycin B is an anthelmintic agent practically used in swine and poultry farming[1].
[1]. Tang W, et al. d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2818-2823.
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