Dabigatran-d3 (Synonyms: BIBR 953-d3; BIBR 953ZW-d3) |
| カタログ番号GC49682 |
ダビガトランの定量化のための内部標準物質
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1246817-44-6
Sample solution is provided at 25 µL, 10mM.
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Dabigatran-d3 is intended for use as an internal standard for the quantification of dabigatran by GC- or LC-MS. Dabigatran is an inhibitor of thrombin (Ki = 0.0045 µM) and an active metabolite of the thrombin inhibitor prodrug dabigatran etexilate .1,2 It also inhibits trypsin (Ki = 0.0503 µM) but is selective for thrombin and trypsin over plasmin, Factor Xa, activated protein C, and tissue plasminogen activator (tPA; Kis = 1.695, 3.76, 20.93, and 45.36 µM, respectively).1
1.Hauel, N.H., Nar, H., Priepke, H., et al.Structure-based design of novel potent nonpeptide thrombin inhibitorsJ. Med. Chem.45(9)1757-1766(2002) 2.Eisert, W.G., Hauel, N., Stangier, J., et al.Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombinArterioscler. Thromb. Vasc. Biol.30(10)1885-1889(2010)
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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