(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Synonyms: Dehydroxymethylepoxyquinomicin) |
| カタログ番号GC32705 |
(-)-DHMEQ (デヒドロキシメチルエポキシキノマイシン) (デヒドロキシメチルエポキシキノマイシン) は、システイン残基に共有結合する強力で選択的かつ不可逆的な NF-κB 阻害剤です。
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Cas No.: 287194-40-5
Sample solution is provided at 25 µL, 10mM.
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(-)-DHMEQ is a potent NF-κB inhibitor.
(-)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (-)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (-)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1].
[1]. Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677. [2]. Kang J, et al. Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation. Toxicology. 2018 May 14;404-405:49-58.
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