DL-Propargyl Glycine (hydrochloride) (Synonyms: PAG) |
| カタログ番号GC43492 |
水素硫化物（H2S）は、自然発生するガストランスミッターであり、強力な血管拡張作用と炎症性介在物質です。
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Cas No.: 16900-57-5
Sample solution is provided at 25 µL, 10mM.
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Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.
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