DMA-135 hydrochloride |
| カタログ番号GC64636 |
DMA-135 塩酸塩は、エンテロウイルス 71 (EV71) IRES 依存の翻訳と複製を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2237925-62-9
Sample solution is provided at 25 µL, 10mM.
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DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].
[1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.
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