Efaproxiral Sodium |
| カタログ番号GC14586 |
エファプロキシラール ナトリウム (RSR13 ナトリウム) は、ヘモグロビン (Hb) の合成アロステリック修飾因子であり、Hb-酸素 (O2) 結合親和性を低下させ、放射線療法中の低酸素腫瘍の酸素化を促進します。
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Cas No.: 170787-99-2
Sample solution is provided at 25 µL, 10mM.
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Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
References:
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.
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