EN40 |
| カタログ番号GC38909 |
EN40 は、共有結合リガンドとして強力な選択的アルデヒド脱水素酵素 3A1 (ALDH3A1) 阻害剤であり、2 uM の IC50 値を示します。
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Cas No.: 2094547-67-6
Sample solution is provided at 25 µL, 10mM.
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EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]
EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1]. Cell Viability Assay[1] Cell Line: A549 cells
EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1]. Animal Model: SCID mice with A549 cells[1]
[1]. Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol. 2018 Aug 17;13(8):1970-1977
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