Esomeprazole (Synonyms: (–)-Omeprazole, (S)-Omeprazole) |
| カタログ番号GC48984 |
エソメプラゾール ((S)-オメプラゾール) は強力な経口活性プロトンポンプ阻害剤であり、胃壁細胞の H+、K+-ATPase の阻害により酸分泌を減少させます。
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Cas No.: 119141-88-7
Sample solution is provided at 25 µL, 10mM.
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Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole .1 It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD), H. pylori eradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.
1.Shin, J.M., and Sachs, G.Restoration of acid secretion following treatment with proton pump inhibitorsGastroenterology123(5)1588-1597(2002)
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