M89 |
| カタログ番号GC36521 |
M-89 は非常に強力で特異的なメニン阻害剤であり、メニンへの結合の Kd は 1.4 nM です。
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Cas No.: 2363165-42-6
Sample solution is provided at 25 µL, 10mM.
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M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1]. Kd: 1.4 nM (menin)[1].
[1]. Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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