NG 52 (Synonyms: Compound 52) |
| カタログ番号GC36732 |
NG 52 は、それぞれ 7 μM と 2 μM の IC50 を持つ強力な細胞透過性、選択的、ATP 適合性、経口活性の Cdc28p および Pho85p キナーゼ阻害剤です。 NG 52 は、ホスホグリセリン酸キナーゼ 1 (PGK1) の活性も 2.5 μM の IC50 で阻害します。 NG 52 は、酵母キナーゼ Kin28p、Srb10、および Cak1p に対して不活性です。
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Cas No.: 212779-48-1
Sample solution is provided at 25 µL, 10mM.
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NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM). cdc2-cyclin B|0.34 μM (IC50)|Pho85p|2 nM (IC50)
[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.
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