Quarfloxin (Synonyms: CX-3543) |
| カタログ番号GC37051 |
抗腫瘍活性を有するフルオロキノロン誘導体であるクアルフロキシン (CX-3543) は、神経芽腫細胞においてナノモル範囲の IC50 値で RNA pol I 活性を標的にして阻害します。クアルフロキシンは、ヌクレオリンタンパク質とリボソーム DNA (rDNA) テンプレートの G-四重鎖 DNA 構造との間の相互作用を破壊します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 865311-47-3
Sample solution is provided at 25 µL, 10mM.
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Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1]. RNA pol I[1].
Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].
[1]. Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.
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