UDM-001651 |
| カタログ番号GC37852 |
UDM-001651 は、強力で、選択的で、経口で生物学的に利用可能なプロテアーゼ活性化受容体 4 (PAR4) アンタゴニストです (IC50=4 nM; Kd=1.4 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1477497-01-0
Sample solution is provided at 25 µL, 10mM.
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UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1]. IC50: 4 nM (PAR4)[1]Kd: 1.4 nM (PAR4)[1]
[1]. Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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