S29434 (Synonyms: NMDPEF) |
| カタログ番号GC38451 |
S29434 (NMDPEF) は、キノンレダクターゼ 2 (QR2) の強力で競合的、選択的かつ細胞透過性の阻害剤であり、さまざまな組織レベルでのヒト QR2 に対する IC50 は 5 ～ 16 nM の範囲であり、QR1 よりも QR2 に対して優れた選択性があります。
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Cas No.: 874484-20-5
Sample solution is provided at 25 µL, 10mM.
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S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production[1].
[1]. Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285.
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