C-178 |
| カタログ番号GC38494 |
C-178 は、強力かつ選択的な STING の共有結合阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 329198-87-0
Sample solution is provided at 25 µL, 10mM.
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C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].
[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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