L-Methionine-(S,R)-Sulfoximine |
| カタログ番号GC45502 |
L-メチオニン-(S,R)-スルホキシミン (MSX) は、グルタミン合成酵素の阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15985-39-4
Sample solution is provided at 25 µL, 10mM.
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L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine.1 It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 μM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.2
References
1. Sinden, S.L., and Durbin, R.D. Glutamine synthetase inhibition: Possible mode of action of wildfire toxin from Pseudomonas tabaci. Nature 219(5152), 379-380 (1968).
2. Reif-Lehrer, L., and Coghlin, J. Conversion of glutamic acid to glutamine by retinal glutamine synthetase. Exp. Eye. Res. 17(4), 321-328 (1973).
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