Homocitrulline-d3 (Synonyms: ε-Carbamyllysine-d3, L-ε-Amino-Carbamoyl-Lysine-d3) |
カタログ番号GC49496 |
ホモシトルリンの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
Homocitrulline-d3 is intended for use as an internal standard for the quantification of homocitrulline by GC- or LC-MS. Homocitrulline is an amino acid and a product of carbamylation, a post-translational modification of proteins and amino acids.1,2 It is formed by the adduction of isocyanic acid, a product of urea degradation or thiocyanate oxidation induced by myeloperoxidase (MPO), to the ε-amino group of lysine residues.2 Protein-bound homocitrulline levels are increased in the aortas of transgenic Ldlr-/- mice expressing human MPO fed a high-fat atherogenic diet.3 Intra-articular injection of homocitrulline-containing peptides induces the development of arthritis in mice.4 Homocitrulline-containing peptide and anti-homocitrulline antibody levels are increased in whole blood from patients with erosive rheumatoid arthritis compared to patients with non-erosive rheumatoid arthritis.
1.Shi, J., Knevel, R., Suwannalai, P., et al.Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damageProc. Natl. Acad. Sci. USA108(42)17372-17377(2011) 2.Verbrugge, F.H., Tang, W.H.W., and Hazen, S.L.Protein carbamylation and cardiovascular diseaseKidney Int.88(3)474-478(2015) 3.Wang, Z., Nicholls, S.J., Rodriquez, E.R., et al.Protein carbamylation links inflammation, smoking, uremia and atherogenesisNat. Med.13(1)1176-1184(2007) 4.Mydel, P., Wang, Z., Brisslert, M., et al.Carbamylation-dependent activation of T cells: A novel mechanism in the pathogenesis of autoimmune arthritisJ. Immunol.184(12)6882-6890(2010)
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(Based on Reviews and 31 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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