Hosenkoside A |
| カタログ番号GC33647 |
ホセンコシド A は、インパチェンス バルサミナの種子から分離されたバッカラン配糖体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 156791-82-1
Sample solution is provided at 25 µL, 10mM.
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Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina.
The mean peak concentrations of hosenkoside A in rats after oral administration of total saponins of Semen Impatientis is 162.08±139.87 ng/mL, occurring at times of 0.67 h. The terminal half-lives of hosenkoside A is 5.39±2.06h[1].
[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).
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Animal experiment: |
Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing. |
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References: [1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3). |
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| Cas No. | 156791-82-1 | SDF | |
| Formula | C48H82O20 | M.Wt | 979.15 |
| 溶解度 | DMSO : 50 mg/mL (51.06 mM; Need ultrasonic) | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.0213 mL | 5.1065 mL | 10.2129 mL |
| 5 mM | 0.2043 mL | 1.0213 mL | 2.0426 mL |
| 10 mM | 0.1021 mL | 0.5106 mL | 1.0213 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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