Indophagolin |
カタログ番号GC61565
One-Click Copy Product Info
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インドファゴリンは、強力なインドリン含有オートファジー阻害剤です (IC50=140 nM)。インドファゴリンは、プリン作動性受容体 P2X4 ならびに P2X1 および P2X3 にそれぞれ 2.71、2.40 および 3.49 μM の IC50 で拮抗します。インドファゴリンは、Gq タンパク質共役 P2Y4、P2Y6、および P2Y11 受容体にも拮抗します (IC50s = 3.4~15.4 μM)。インドファゴリンは、セロトニン受容体 5-HT6 に対して強力な拮抗作用 (IC50=1.0 μM) を持ち、受容体 5-HT1B、5-HT2B、5-HT4e、および 5-HT7 に対して中程度の作用を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1207660-00-1
Sample solution is provided at 25 µL, 10mM.
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Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].
Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1].
[1]. Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1.
| Cas No. | 1207660-00-1 | SDF | |
| Canonical SMILES | O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O | ||
| Formula | C19H15BrClF3N2O3S | M.Wt | 523.75 |
| 溶解度 | Storage | 4°C, protect from light | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9093 mL | 9.5465 mL | 19.0931 mL |
| 5 mM | 381.9 μL | 1.9093 mL | 3.8186 mL |
| 10 mM | 190.9 μL | 954.7 μL | 1.9093 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)